| Registro completo | |
|---|---|
Accedir a l'exemplar |
|
| Títol: |
Trastuzumab Response in Iraqi Women with Her2 Positive Breast Cancer: The Role of PIK3CA Oncogene Mutations at E542k and E545k |
| Autor/es | Hammadi, Alyaa H. ; Ali, Shatha H. |
| Matèries en català: | Mama -- Càncer ; Ciències de la Salut ; Medicina |
| Matèries en castellà: | Mamas -- Cáncer ; Ciencias de la salud ; Medicina |
| Matèries en anglès: | Breast -- Cancer ; Health Sciences ; Medicine |
| Abstract: | [eng] Introduction: Breast cancer (BC) frequently carries PIK3CA mutations. These frequently include the helical domains and exon 10 of the protein kinase, which can activate it. In addition to being expensive, trastuzumab, a human epidermal growth factor receptor 2 antagonist, is ineffective in 20% to 25% of patients with related Her2-positive BC. The response to treatment is significantly influenced by genetic differences. The study’s goal was to determine whether the presence of PIK3CA polymorphism at sites on E542k and E545k would affect Iraqi patients with Her2-positive breast cancer’s propensity to respond to trastuzumab (TRS) or not. in addition to cardiac toxicity. Method: The Department of Oncology/Diwaniya University Hospital recruited 60 Her2-positive Iraqi BC women who had been receiving TRS for at least 1 year. Patients were divided into non-responders and responders using the Response Evaluation Criteria in Solid Tumors (RECIST). After DNA amplification by polymerase chain reaction, the DNA was sequenced using the Sanger method to detect polymorphisms at positions E542k and E545k. Result: Data analysis revealed that there was no statistically significant association between Her2 promoter region E542k and E545k polymorphism and the propensity to respond positively to TRS. Reactive and unresponsive females had a very significant difference in the frequency of the combination of mutations. |
| Font: | Academic Journal of Health Sciences 2024, Vol. 39, n.2, pp. 46-52 |
| Identificador: | doi: 10.3306/AJHS.2024.39.02.46 |
| Tipus de document: | info:eu-repo/semantics/article ; info:eu-repo/semantics/publishedVersion |
| Avís legal: | All rights reserved ; info:eu-repo/semantics/openAccess |